Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo

Jimmy K. Guo, Mario R. Blanco, Ward G. Walkup, Grant Bonesteele, Carl R. Urbinati, Abhik K. Banerjee, Amy Chow, Olivia Ettlin, Mackenzie Strehle, Parham Peyda, Enrique Amaya, Vickie Trinh, Mitchell Guttman

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)1271-1289.e12
JournalMolecular Cell
Volume84
Issue number7
DOIs
StatePublished - Apr 4 2024

ASJC Scopus Subject Areas

  • Molecular Biology
  • Cell Biology

Keywords

  • chromatin
  • CLIP
  • PRC2
  • RNA
  • RNA-binding proteins
  • RNA, Long Noncoding/genetics
  • Animals
  • Humans
  • Chromatin/genetics
  • Polycomb Repressive Complex 2/genetics
  • Mice
  • Binding Sites

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