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Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo

  • Jimmy K. Guo
  • , Mario R. Blanco
  • , Ward G. Walkup
  • , Grant Bonesteele
  • , Carl R. Urbinati
  • , Abhik K. Banerjee
  • , Amy Chow
  • , Olivia Ettlin
  • , Mackenzie Strehle
  • , Parham Peyda
  • , Enrique Amaya
  • , Vickie Trinh
  • , Mitchell Guttman
  • University of Southern California
  • California Institute of Technology

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)1271-1289.e12
JournalMolecular Cell
Volume84
Issue number7
DOIs
StatePublished - Apr 4 2024

ASJC Scopus Subject Areas

  • Molecular Biology
  • Cell Biology

Keywords

  • chromatin
  • CLIP
  • PRC2
  • RNA
  • RNA-binding proteins
  • RNA, Long Noncoding/genetics
  • Animals
  • Humans
  • Chromatin/genetics
  • Polycomb Repressive Complex 2/genetics
  • Mice
  • Binding Sites

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