Investigating Metal Cations as Potential Inhibitors of IAPP Aggregation: KCl, CaCl2, and CuCl2

Megan Burke

Investigating Metal Cations as Potential Inhibitors of IAPP Aggregation: KCl, CaCl2, and CuCl2

Megan Burke

Research output: Thesis › Honors Thesis

Abstract

IAPP is an amyloid protein that misfolds, causing toxic aggregation in the pancreas of Type II Diabetes patients. In this study, three metal cations (KCl, CaCl2, and CuCl2) are tested in Thioflavin T assays and atomic force microscopy (AFM) to see if they inhibit the aggregation of IAPP.

Original language	English
Awarding Institution	Loyola Marymount University
Supervisors/Advisors	Moffet, David A., Advisor
State	Published - May 2 2016
Externally published	Yes

Access to Document

http://digitalcommons.lmu.edu/honors-thesis/106

Cite this

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title = "Investigating Metal Cations as Potential Inhibitors of IAPP Aggregation: KCl, CaCl2, and CuCl2",

abstract = "IAPP is an amyloid protein that misfolds, causing toxic aggregation in the pancreas of Type II Diabetes patients. In this study, three metal cations (KCl, CaCl2, and CuCl2) are tested in Thioflavin T assays and atomic force microscopy (AFM) to see if they inhibit the aggregation of IAPP.",

author = "Megan Burke",

year = "2016",

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day = "2",

language = "English",

series = "Honors Thesis",

type = "Honors Thesis",

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AU - Burke, Megan

PY - 2016/5/2

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N2 - IAPP is an amyloid protein that misfolds, causing toxic aggregation in the pancreas of Type II Diabetes patients. In this study, three metal cations (KCl, CaCl2, and CuCl2) are tested in Thioflavin T assays and atomic force microscopy (AFM) to see if they inhibit the aggregation of IAPP.

AB - IAPP is an amyloid protein that misfolds, causing toxic aggregation in the pancreas of Type II Diabetes patients. In this study, three metal cations (KCl, CaCl2, and CuCl2) are tested in Thioflavin T assays and atomic force microscopy (AFM) to see if they inhibit the aggregation of IAPP.

M3 - Honors Thesis

T3 - Honors Thesis

ER -