SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress

  • Erica Wolin
  • , Jimmy K. Guo
  • , Mario R. Blanco
  • , Isabel N. Goronzy
  • , Darvesh Gorhe
  • , Wenzhao Dong
  • , Andrew A. Perez
  • , Abdurrahman Keskin
  • , Elizabeth Valenzuela
  • , Ahmed A. Abdou
  • , Carl R. Urbinati
  • , Ross Kaufhold
  • , H. Tomas Rube
  • , Jailson Brito Querido
  • , Mitchell Guttman
  • , Marko Jovanovic

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)5384-5402.e25
JournalCell
Volume188
Issue number19
Early online dateJul 22 2025
DOIs
StatePublished - Sep 18 2025

ASJC Scopus Subject Areas

  • General Biochemistry,Genetics and Molecular Biology

Keywords

  • CLIP
  • LARP1
  • mTOR
  • ribosome
  • RNA
  • RNA-binding proteins
  • translation
  • Protein Biosynthesis
  • Humans
  • Stress, Physiological
  • Cell Cycle Proteins/metabolism
  • Autoantigens/metabolism
  • Ribonucleoproteins/metabolism
  • SS-B Antigen
  • Adaptor Proteins, Signal Transducing/metabolism
  • RNA, Messenger/metabolism
  • RNA-Binding Proteins/metabolism
  • Cryoelectron Microscopy
  • RNA, Ribosomal, 18S/metabolism
  • TOR Serine-Threonine Kinases/metabolism
  • Binding Sites

Cite this